Charles Pelizzari, Ph.D.

Professor of Radiation and Cellular Oncology

Research Summary

Dr. Pelizzari spent his early years in the Detroit area, and attended the University of Michigan, graduating with a Ph.D. in Nuclear Engineering in 1974 under the direction of John M. Carpenter. He spent 8 years as a staff physicist at Argonne National Laboratory, using thermal neutron scattering to study structure and dynamics of solids and fluids. He was a member of the first experimental group to observe dispersion of collective excitations in the Fermi liquid phase of Helium-3 at low temperature (0.01K) using neutrons, and of the original design team for the experimental facilities at Argonne's Intense Pulsed Neutron Source.

In 1982 he joined the University of Chicago in the Section of Radiation Therapy of the Radiology Department, which became the Department of Radiation and Cellular Oncology in 1985. His responsibilities have included development of computer software for planning of various therapy techniques including external photon beam therapy, interstitial and intracavitary brachytherapy, including ultrasound-guided 125I prostate seed implants. He collaborated with colleagues in Dr David Levin's laboratory in Radiology to develop techniques for synthesis and 3D display of information from multiple medical image studies into a single consistent framework so they may be used for accurate diagnosis and therapy planning, and to develop a system for image guidance of neurosurgery.

His current research interests include visualization of multimodality 3D information from medical image data and its application to diagnosis and image guidance of therapy procedures; optimization of intensity modulated radiotherapy; incorporation of uncertainty into design and delivery of therapy; communication and storage of medical image data; and application of quantitative film dosimetry techniques to autoradiography.

Publications

  • Pederson, A.W., et al., Late toxicity after intensity-modulated radiation therapy for localized prostate cancer: an exploration of dose-volume histogram parameters to limit genitourinary and gastrointestinal toxicity. Int J Radiat Oncol Biol Phys, 2012. 82(1): p. 235-41.
  • Liauw, S.L., et al., Evaluation of the Prostate Bed for Local Recurrence After Radical Prostatectomy Using Endorectal Magnetic Resonance Imaging. Int J Radiat Oncol Biol Phys, 2012.
  • Haney, C.R., et al., HiSStology: high spectral and spatial resolution magnetic resonance imaging detection of vasculature validated by histology and micro-computed tomography. Mol Imaging, 2011. 10(3): p. 187-96.
  • Fan, X., et al., High-resolution MRI of excised human prostate specimens acquired with 9.4T in detection and identification of cancers: validation of a technique. J Magn Reson Imaging, 2011. 34(4): p. 956-61.
  • Elas, M., et al., Where it's at really matters: in situ in vivo vascular endothelial growth factor spatially correlates with electron paramagnetic resonance pO2 images in tumors of living mice. Mol Imaging Biol, 2011. 13(6): p. 1107-13.